Chromium picolinate Chinese Synonyms: chromium picolinate (III); chromium picolinate; chromium picolinate; formylpyridine chromium; pyridine potassium acid lattice; 2- chromium picolinate; 2- formylpyridine chromium (III); 2- pyridinecarboxamide chromium salts English name: Picolinic acid chromium (III) salt Synonyms: chromium (iii) trispicolinate; chromium2-pyridinecarboxylate; tris (2-pyridinecarboxylato-n (1), o (2)) - chromiu; tris (picolinato) - chromiu; [TRIS (PYRIDIN-2-CARBOXYLATE)] CHROMIUM (III); PICOLINIC ACID CHROMIUM (3) SALT; PICOLINIC ACID CHROMIUM (III) SALT; PICOLINIC ACID CHROMIUM SALT CAS Number: 14639-25-9 Formula: C18H12CrN3O6 MW: 418.3 Features chromium picolinate look tiny purple crystalline powder, good liquidity, chemically stable at room temperature, slightly soluble in water, soluble in ethanol, in which chromium is trivalent chromium. The entire molecular structure is electrically neutral, and hydrophobic properties, it is possible to complete the structure of transmembrane absorption, molecular structure partially similar to GTF. In 1977, Toepfer GTF is considered biologically active form of chromium, having the structure niacin - chromium - nicotinic acid ligand with aspartic acid, glutamic acid, glycine, cysteine ??formation. GTF chromium picolinate class structure determines its own good absorption rate, and can more effectively play their biological functions. It is reported that the absorption rate of the formulation of ordinary chromium 0.5%, while chromium picolinate absorption rate 2% -5% (Anderson, 1996). Chromium picolinate is a muscle strengthening and promote weight loss supplement, can improve the metabolic pathways in skeletal muscle cells associated with the activity of AMP protein kinase (AMPK) in an amount to improve the energy balance and insulin action. The main effect is as follows: 1, to improve the proportion of lean meat, lower fat, improve carcass quality. 2, improve stress resistance and immunity. Stress can cause animal production, niacin chromium by anti-stress effect can increase production of animal products. Chromium is an essential mineral, it is carbohydrates, fat and protein metabolism in essential substance release of insulin activity. August 2005, the US Food and Drug Administration (FDA) approved the production of chromium picolinate, and confirmed that it can be safely used in human insulin resistance and type Ⅱ diabetes. The main basis for FDA to make this judgment was Dr. Cefalu earlier randomized, double-blind studies and comfort therapy, chromium picolinate can significantly improve the high-risk diabetic patients insulin sensitivity. Dietary Reference Intakes chromium (adults) AI = 50ug / day of Chinese Residents in China to develop, UL = 500ug / day. In the "declaration of nutrient supplements and review provisions", the minimum amount of chromium is 15ug / day, the maximum amount is 150ug / day. Chromium Chromium is an essential element of one of the 12 kinds of trace metals, chromium Cr nature to Cr6 + various valence states, but Cr, Cr2 +, Cr3 +, Cr6 + the most common. Cr3 + is an essential trace element chromium in the human body is almost entirely Cr3 +, which is a component of glucose tolerance factor, with the insulin-like effects, can promote glucose utilization cells, promote the oxidation of glucose phosphorylation, promote glycogen synthesis, improve the stability of insulin, thereby reducing blood sugar. Its physiological role increasingly researchers attention. Studies have shown that: Chrome and glucose metabolism, is closely related to lipid metabolism, protein metabolism, and nucleic acid metabolism. Also found that a variety of animals on chromium tolerance are stronger. Tolerable chromium oxide 3000mg / kg, chromium chloride tolerable 1000mg / kg. Chromium as chromium picolinate organic formulations, their safety is also a growing concern. On livestock production, chromium picolinate for mitigation of environmental stress, increase lean meat, increase endurance significantly promoted, and is widely used. But their usage, although some countries have ratified adding chromium picolinate in animal diets, but has not yet officially released the animals minimum requirement and maximum tolerated dose data. Studies have reported that normal physiological plasma concentrations of chromium for 0.1-2.1μg / ml (Cerulli et al., 1998), physiological concentrations of chromium in human liver was 5.4-470ηg ??/ g liver wet weight (-0.1-9μM) (Versieck, 1985), excess added (much higher than physiologic doses) may produce toxicity DNA and cytotoxicity. Note the current domestic and international research institutes and institutions of Nutrition showed that long-term intake of chromium ≥1000ug / day, easily lead poisoning. Maximum allowable consumption of health food 250ug / day. An excess of iron and zinc can interfere with and inhibit the absorption of chromium. 2, manganese and chromium have mutually reinforcing roles in the regulation of glucose metabolism. 3, chromium and magnesium can promote collaborative sugars. 4, no increase in protein and lysine daily sugar levels. Use as a medicine and health products, food additives. Content: 98-102% chromium content: 12.18-12.66% Sulfate: ≤0.2% Chloride: ≤0.06% Heavy Metal: ≤0.001% Arsenic: ≤0.0005% Loss on drying: ≤3% fineness: 99% 80 mesh dissolved sex: slightly soluble in water, insoluble in ethanol. Packing: 25KG cardboard Price: 205 / KG free shipping